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The friends Emmett, Freddy, Marie, Kevin and his reluctant girlfriend Jessie decide to spend the Halloween night in an abandoned hospital. Meanwhile, the younger Allan meets the old friend of his father Arlo Ray Baines and asks him to help to find his vanished sister Meg in the same spot. The two groups meet each other in the mental institution section on the haunted third floor and they find that they are trapped in the place. Jessie has visions from the past and discovers that the ghost of Jacob, a former patient that raped a little girl and burned the hospital, is trying to escape possessing their bodies that melt down with his evil spirit.

The veteran Vietnam lieutenant Jake Neeley lives alone in a cabin in the woods and his only contact with the civilization is through the owner of a small store, Kate, who periodically supplies his provisions. The solitary Jake helps other lonely veterans that live in the forest giving them part of his supplies and receiving wood in return. When Jake is visited by the former private of his platoon Henry R. Hocknell, who has lung cancer, Henry asks him to raise his Vietnamese daughter Lenny Hocknell. The widow Henry has no family and he will be subjected to a severe treatment of cancer. The reluctant Jake says no, but Henry leaves his daughter and vanishes. Along his contact with the young girl, Jake improves his behavior until a tragedy happens.

The preschool teacher Sarah (Diane Lane) divorced from her beloved husband eight moths ago, but she is still very vulnerable and alone. Her family presses her to find a new Mr. Right, and her sister Carol (Elizabeth Perkins) puts her profile on the site PerfectMatch.com. She has blind dates with odd guys, but she particularly likes Jake (John Cusack), who divorced three months ago and still misses his former wife. Jake likes her too, but Sarah has one night stand with Bob (Dermot Mulroney), the father of one of her students, and Jake gives-up on her. Later Sarah finds that Jake is her perfect match.

In the 1970s, a foundling lad, Patrick “Kitten” Braden, comes of age by leaving his Irish town for London, in part to look for his mother and in part because his trans-gender nature is beyond the town’s understanding.