A simple-minded gardener named Chance has spent all his life in the Washington D.C. house of an old man. When the man dies, Chance is put out on the street with no knowledge of the world except what he has learned from television. After a run in with a limousine, he ends up a guest of a woman (Eve) and her husband Ben, an influential but sickly businessman. Now called Chauncey Gardner, Chance becomes friend and confidante to Ben, and an unlikely political insider.

Six different people, each from a very different walk of life, awaken to find themselves inside a giant cube with thousands of possible rooms. Each has a skill that becomes clear when they must band together to get out: a cop, a math whiz, a building designer, a doctor, an escape master, and a disabled man. Each plays a part in their thrilling quest to find answers as to why they’ve been imprisoned.

Two hundred years after Mary Shelley’s novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O’Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil.

Charley is a hustler. He’s been on his own long enough to know how to work people and situations. He finds that the father who threw him out as a teen ager has died. He’s left him a now antique convertible and something more important, a previously unknown brother, Raymond. Raymond is Autistic, but is able to calculate complicated mathematical problems in his head with great speed and accuracy. Their father has left his fortune to Raymond who doesn’t even understand what money is for. Charley is enraged by what has happened and by his father keeping Raymond’s existence from him for his entire life. He kidnaps Raymond from his residential home but then finds that Raymond will only fly Qantas. The two begin a long road trip that will lead them to an understanding of each other.