This is the story of three gentle persons: Paul Rivers (Penn) an ailing mathematician lovelessly married to an English emigré (Gainsbourg), Christina Peck, an upper-middle-class suburban housewife, happily married and mother of two little girls, and Jack Jordan (Del Toro), an ex-convict who has found in his Christian faith the strength to raise a family. They will be brought together by a terrible accident that will change their lives. By the final frame, none of them will be the same as they will learn harsh truths about love, faith, courage, desire and guilt, and how chance can change our worlds irretrievably, forever.

Alan Johnson has everything he needs to get through life: a good job, a beautiful and loving wife, and their wonderful children. Yet he feels isolated because he finds having a hard-working job and managing a family too much to handle and has no one to talk to about it. Charlie Fineman, on the other hand, doesn’t have a job or a family. He used to have both until he lost his family on the fateful day of 9/11, and the grief he felt caused him to quit his job and isolate himself from everyone around him. As it turns out, Alan and Charlie were roommates in college, and a chance encounter one night rekindles the friendship they shared. They soon feel that their friendship is the one thing that allows them to forget about their problems.

Marlin (a clown fish) is a widower who only has his son Nemo left of his family after a predator attack. Years later, on Nemo’s first day of school, he’s captured by a scuba diver and taken to live in a dentist office’s fish tank. Marlin and his new absent-minded friend Dory set off across the ocean to find Nemo, while Nemo and his tankmates scheme on how to get out of the tank before he becomes the dentist’s niece’s new pet.