Dr. John Dolittle has the world in his hands: A beautiful wife at his side, two adorable daughters and a career that could not go better. One night, he nearly runs over a dog with his car. The dog yells “bonehead” and disappears. From then on, his childhood ability is back: To communicate with animals. Unfortunately, the word of Dolittle’s ability is spreading quickly. Soon, many animals from rat to horse flock to his place to get medical advice. But his colleagues suspect he’s going mad, and as the clinic Dolittle used to work for is about to being taken over for a huge amount of money, many decisions have to be made. Believe him? Put him into a mental institution? Sell the clinic? But also his family is close to breaking apart. Until a circus tiger falls seriously ill.

Barely escaping from nefarious dognappers, an adorable puppy named Beethoven adopts the unsuspecting Newton family — and promptly grows up into 185 pounds of romping, drolling, disaster-prone St. Bernard! Unfortunately, even after proving his canine credentials to mom and the kids, the heroic hound gets nowhere with uptight dad, George (Charles Grodin). But when a beastly veterinarian (Dean Jones) makes Beethoven the target of an unspeakable animal experiment, George becomes the only hope for saving the Newton’s furriest family member.

Little Nicky is “daddy’s little girl” in Hell. He’s the son of Satan, who got the job from HIS father, Lucifer. Satan wants to retire, but none of his sons are good enough for the job. There’s Cassius, who’s big and strong, but lacks the ‘goodness’ to make the job real. There’s Adrian, who while really hot (no pun intended) and smart, has no goodness at all. Then there’s Nicky [Sandler] who, while having good, lacks any evil whatsoever. As seen in the previews, he is told to release his evil. He needs to release it to save his dad. Cassius and Adrain leave Hell, thereby freezing the wall of fire that lets the damned souls into Hell. Since no souls can come in now, Satan starts to die. It’s up to Little Nicky to go and get his brothers, putting them into a flask and bringing them back to Hell at the exact same time to save Satan from decomposition. If Nicky ‘dies’ on Earth, he will be able to get through the frozen wall and back up to Earth. The catch is that he has only a week, and that Adrian and Cassius are MUCH more powerful than he is.

During FBI operation Agent Eleven (Bob), a drug-sniffing dog, happens to bite off a major mobster’s manhood. The gangster cuts up quite savage and orders two hit men to murder the dog. To secure the canine agent, the FBI places him in the witness protection program. The dog changes both his owners and his name. Now he is adopted by a postal worker, Gordon Smith (David Arquette), who is not exactly a dog lover. One fine day when Gordon’s beautiful neighbor, Stephanie (Leslie Bibb), asks him to baby-sit her son, it is a challenge for Gordon to handle the pet. The super dog makes friends with James (Angus T. Jones), trees the mailman, evades the mobsters’ pursuit and gets sympathy of all kids in the neighborhood. “Spot” is full of energy while waiting for his enemies to track down him again. It remains to be seen who will lead a dog’s life!