A man in a suit at a Manhattan firm leaves work on Friday; he looks unhappy. He stops at a fortune teller’s for a Tarot reading: “You are not where you belong,” she tells him. That evening he quits his marriage and walks the streets of New York, passing from a classy bar to a gentleman’s club, then to a high-class bordello, a mugging, a pawnshop, and a diner where someone does listen. He shares his insights with her and later with others. Violence, disappointment, and musings entwine as Edmond loses his moorings while believing he’s found them. Where does he belong?

An unknown and lethal virus has wiped out five billion people in 1996. Only 1% of the population has survived by the year 2035, and is forced to live underground. A convict (James Cole) reluctantly volunteers to be sent back in time to 1996 to gather information about the origin of the epidemic (who he’s told was spread by a mysterious “Army of the Twelve Monkeys”) and locate the virus before it mutates so that scientists can study it. Unfortunately Cole is mistakenly sent to 1990, six years earlier than expected, and is arrested and locked up in a mental institution, where he meets Dr. Kathryn Railly, a psychiatrist, and Jeffrey Goines, the insane son of a famous scientist and virus expert.

A bright-eyed young actress travels to Hollywood, only to be ensnared in a dark conspiracy involving a woman who was nearly murdered, and now has amnesia because of a car crash. Eventually, both women are pulled into a psychotic illusion involving a dangerous blue box, a director named Adam Kesher, and the mysterious night club Silencio.