The futuristic tale unfolds in a Great Britain that’s a fascist state. A freedom fighter known as V (Weaving) uses terrorist tactics to fight the oppressive society. He rescues a young woman (Portman) from the secret police, and she becomes his unlikely ally.

A war has been raging between the Vampires and Lycan for centuries, Selene (Beckinsale) is a death dealer, assigned to hunt down and eradicate the last of the Lycan. When she comes across Michael Corvin(Speedman)who holds the key to end the war she must decide where her alligances will lie.