This movie continues the saga of war between the Death Dealers (vampires) and the Lycans (werewolves). The film traces the beginnings of the ancient feud between the two tribes as Selene (Kate Beckinsale) and Michael (Scott Speedman), the lycan hybrid, try to discover the secrets of their bloodlines. All of this takes them into the battle to end all wars as the immortals must finally face their retribution.

A war has been raging between the Vampires and Lycan for centuries, Selene (Beckinsale) is a death dealer, assigned to hunt down and eradicate the last of the Lycan. When she comes across Michael Corvin(Speedman)who holds the key to end the war she must decide where her alligances will lie.