Harry Angel is a private investigator. He is hired by a man who calls himself Louis Cyphre to track down a singer called Johnny Favorite. As he begins to investigate, all the people he contacts concerning Johnny are killed in mysterious ways. As he finds out more about himself and his client he discovers that he is fighting for his very existence and is forced to deal with the devil himself.

In order to escape from the abusive boy-friend, Gary Winston (Damian Lewis), Jean Gilkyson (Jennifer Lopez) moves with her young daughter Griff Gilkyson (Becca Gardner) without previous notice to the ranch of her father-in-law Einar Gilkyson (Robert Redford) in Wyoming. Jean and Einar are disaffected, since he blames her for the death of his beloved son in a car accident. Einar is taking care of his friend Mitch Bradley (Morgan Freeman), who was attacked and seriously wounded by a bear, and he does not know that he has a grand-daughter. While Mitch heals his wounds and forgives the bear, Einar also changes his feelings regarding Jean, finally understanding that accidents happen and accepting her and loving his grand-daughter.

While looking for an apartment, Jeanne, a beautiful young Parisienne, encounters Paul, a mysterious American expatriate mourning his wife’s recent suicide. Instantly drawn to each other, they have a stormy, passionate affair, in which they do not reveal their names to each other. Their relationship deeply affects their lives, as Paul struggles with his wife’s death and Jeanne prepares to marry her fiance, Tom, a film director making a cinema-verite documentary about her.

Childhood friends Jimmy Markum (Penn), Sean Devine (Bacon) and Dave Boyle (Robbins) reunite following the death of Jimmy’s oldest daughter, Katie (Rossum). Sean’s a police detective on the case, gathering difficult and disturbing evidence; he’s also tasked with handling Jimmy’s rage and need for retribution.