Charles Dreyfus escapes from the mental asylum and tries to kill Chief Inspector Jacques Clouseau. He doesn’t succeed at first, so he takes on another strategy, namely to build a Doom’s Day machine and demand that someone else kills Jacques Clouseau, or Dreyfus will use the machine to wipe out whole cities and even whole countries… With about 22 assassins from all over the globe on his tail, Clouseau decides to find Dreyfus alone and put him back in the mental asylum.

When rich M. Ballon’s spanish driver is found shot dead, Inspector Jacques Clouseau is the first official on the scene. All evidence suggests Maria Gambrelli, the maid, to be the murderer. But Clouseau, being attracted to the beautiful girl, is convinced that she is hiding something. So, he has her released from jail and tries to follow her secretly. Things do not work out the way the inspector wanted and people keep being murdered, and each time innocent Maria seems to be the killer. But with someone important wanting Clouseau and nobody else to cover this case, his tolerance-challenged boss Charles Dreyfuss is close to losing his mind when casualties keep turning up. And Clouseau keeps on causing trouble without knowing it…