In 2046, in a research facility in Mars, some subjects are released and the place is kept in quarantine. A team of Marines, leaded by Sarge (The Rock), is assigned to rescue the personnel and retrieve the research data, with the support of Dr. Samantha Grimm (Rosamund Pike), the twin sister of the Marine John “Reaper” Grimm (Karl Urban). While in the mission, Samantha finds a dark hidden secret about the monsters and the researches.

Clive Barker’s feature directing debut graphically depicts the tale of a man and wife who move into an old house and discover a hideous creature - the man’s half-brother, who is also the woman’s former lover - hiding upstairs. Having lost his earthly body to a trio of S&M demons, the Cenobites, he is brought back into existence by a drop of blood on the floor. He soon forces his former mistress to bring him his necessary human sacrifices to complete his body… but the Cenobites won’t be happy about this.