In the small town of Knapely, Yorkshire, England, Annie Clarke (Julie Walters) has just lost her husband, who was ill with leukemia. Inspired in his speech to the local Women’s Institute, where he said that “the flowers of Yorkshire are like the women of Yorkshire”, and “the last phase of the women of Yorkshire is always the most glorious”, her best friend Chris Harper (Helen Mirren) decides to make a calendar with twelve local middle-age women nude to raise funds for the wing of leukemia treatment in the local hospital. The calendar becomes well succeeded, making them famous and affecting their lives.

New York City. Melvin Udall, a cranky, bigoted, obsessive-compulsive writer, finds his life turned upside down when neighboring gay artist Simon is hospitalized and his dog is entrusted to Melvin. In addition, Carol, the only waitress who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.