With the end of the North American Civil War, the manufacturers of repeating rifles find a profitable means of making money selling the weapons to the North American Indians, using the front man John Lattimer to sell the rifles to the Cheyenne. While traveling in a stagecoach with Calamity Jane and William “Buffalo Bill” Cody and his young wife Louisa Cody that want to settle down in Hays City managing a hotel, Wild Bill Hickok finds the guide Breezy wounded by arrows and telling that the Indians are attacking a fort using repeating rifles. Hickok meets Gen. George A. Custer that assigns Buffalo Bill to guide a troop with ammunition to help the fort. Meanwhile the Cheyenne kidnap Calamity Jane, forcing Hickok to expose himself to rescue her.

Annie Oakley is an incredible shot who was raised ‘Doin’ What Comes Naturally’. Frank Butler, the star sharpshooter in ‘Colonel Buffalo Bill’’s show, however, knows full well that’s not how ‘The Girl That I Marry’ must be. Anyway, not at least until he finds that ‘My Defences are Down’. Though Annie defiantly says ‘Anything You Can Do I Can Do Better’, she realizes that ‘You Can’t Get a Man With a Gun’. The victor at the end is love; as you know, ‘It’s Wonderful’. After all, ‘There’s No Business Like Show Business’.