In 2046, in a research facility in Mars, some subjects are released and the place is kept in quarantine. A team of Marines, leaded by Sarge (The Rock), is assigned to rescue the personnel and retrieve the research data, with the support of Dr. Samantha Grimm (Rosamund Pike), the twin sister of the Marine John “Reaper” Grimm (Karl Urban). While in the mission, Samantha finds a dark hidden secret about the monsters and the researches.

Based on Marvel Comics’ superhero character, this is a story of Peter Parker who is a nerdy high-schooler. He was orphaned as a child, bullied by jocks, and can’t confess his crush for his stunning neighbourhood girl Mary Jane Watson. To say his life is “miserable” is an understatement. But one day while on an excursion to a laboratory a runaway radioactive spider bites him… and his life changes in a way no one could have imagined. Peter acquires a muscle-bound physique, clear vision, ability to cling to surfaces and crawl over walls, shooting webs from his wrist … but the fun isn’t going to last. An eccentric millionaire Norman Osborn (William Dafoe) administers a performance enhancing drug on himself and his maniacal alter ego Green Goblin emerges. Now Peter Parker has to become Spider-Man and take Green Goblin to the task… or else Goblin will kill him. They come face to face and the war begins in which only one of them will survive at the end.