A man, Joel Barish, heartbroken that his girlfriend Clementine underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realizes that he still loves her, and may be too late to correct his mistake.

After her divorce, Meg Altman and her daughter Sarah move into an old-fashioned house with one very modern addition: a “panic room” which is virtually impossible to break into, designed for refuge during a home invasion. In their first night in the house a trio of thieves do break in and Meg and Sarah rush into the panic room. However, the intruders are looking for something inside the panic room, and given the recent move the room’s hotline to the police hasn’t been hooked up yet. Worse, Sarah is diabetic and the room doesn’t contain any sugar…

A group of college kids, on their way back from scoring drugs in Mexico, run into a hitchhiker who has just survived a horrific massacre from the night before. They try to help the girl, but in the process end up falling prey to her mysterious fear. It happens to be wielding a chainsaw…