Al Lewis and Willy Clark were once a popular vaudeville comedy team called Lewis and Clark, also known as The Sunshine Boys. After forty-three years as a team, they parted company over eleven years prior on not too friendly terms as Willy wanted to continue his career whereas Al wanted to retire. They have not spoken since. Willy’s nephew, Ben - a talent agent - has been trying to find acting jobs for his uncle since with little success as Willy’s age and declining ability is showing. But a lucrative opportunity comes up when one of the major networks is producing and airing a special on the history of comedy, and want The Sunshine Boys to appear. Ben has to try and convince the comedy team to reunite for just this one gig. Ben has to try and manage the individual quirks and personalities of each of The Sunshine Boys while putting on a good face to the network that there is harmony within The Sunshine Boys comedy team. Ben also has to manage the lives of two men in the twilight of their lives.

Tobacco industry lobbyist Nick Naylor has a seemingly impossible task: promoting cigarette smoking in a time when the health hazards of the activity have become too plain to ignore. Nick, however, revels in his job, using argument and twisted logic to place, as often as not, his clients in the positions of either altruistic do-gooders or victims. Nick’s son Joey needs to understand and respect his dad’s philosophy, and Nick works hard to respond to that need without compromising his lack of values. When a beautiful news reporter betrays Nick’s sexually-achieved trust, his world seems in danger of collapsing. But there’s always one more coffin nail in Nick’s pack.

An FBI agent (Reynolds) hunts for a Las Vegas stand up comedian (Piven) who has decided to squeal on the mob but, before he heads off for protective custody, decides to go to the casinos at Lake Tahoe for one last good time, drawing a crowd of assassins (including Affleck and Keys).

Michael Dorsey is desperate; he can’t find a job. That is, until he gets a female role in a soap opera and becomes very famous. Of course, nobody knows that this new television star is a man… But, after a while, he falls in love with the leading actress of the series, and here is the big problem: how can he express his feelings, since she thinks that Michael is a woman?