There is a serial killer on the loose, Karen White is the only reporter he communicates with. After a near fatal encounter with him at a Pussycat Theater, she is ordered to take a vacation. Eddie was killed by Police, but Karen doesn’t want to let it go and discovers that he came from a tiny community in the woods and that’s where she decides to vacation with boyfriend Chris. Big mistake, because Eddie was an outcast of a pack of Werewolves who is trying to keep a low profile and doesn’t want any interviews. Can Karen and Chris escape the village of the wolf?

Bounty hunter Jack Walsh is sent to find and return bail jumper and former Mafia accountant, Jonathan “The Duke” Mardukas. The FBI have had no success it locating The Duke, so when Jack finds him in next to no time, they are a little embarrassed. In order to collect his $100,000 fee, Jack must take The Duke from New York to Los Angeles. However, the Mafia and the FBI have other ideas, as does Marvin, a rival bounty hunter. On their long cross-country trip to LA, the two get to know each other and they build up a strange friendship.

An out-of-control speed freak (Schwartzman) is introduced his drug of choice’s creator (Rourke) by his dealer (Leguizamo). A massive three-day adventure ensues (with Fugit, Murphy, and Suvari in tow).